Good day, athletes and novice bodybuilders!
The information provided below is for informational purposes only, where we will explain in detail the correct and effective use of growth hormone, as well as practical tips and additions to the course.
Note that we have the first part of the article about somatotropin, which tells about the drug itself, effects, research and interesting facts. If you haven’t read it yet, we recommend that you read it!
These courses are designed to help novice athletes achieve a sculpted figure. The dosages and combinations described below are taken from scientific literature and are based on the experience of using anabolic agents in various sports.
Who are these courses suitable for?
The products for stimulating hormone production can be used by both men and women over the age of 20 (at a younger age, asymmetrical bone development is possible). The main purpose of use is to enhance muscle definition by reducing the fat layer. The total body weight, as a rule, increases slightly.
Recommendations (advice):
- The course should be carried out under strict control of blood sugar levels.
- It is necessary to adjust the use of insulin during the course of somatotropin.
- Monitoring. In the first two to three weeks of the course, you should especially carefully monitor blood glucose levels using a glucometer.
Insulin correction is a key point:
Concerning people with diabetes: The use of anabolic agents by people with diabetes requires special attention and monitoring of blood glucose levels.
When using somatotropin (usually up to 10 IU per day), a small adjustment of the insulin dose may be required - on average, an increase of 1-3 units before each meal (20-30 minutes). For experienced diabetics, this will not be a big deal. It is important to regularly measure blood sugar levels and adapt the insulin dose in accordance with the indicators.
Despite the difficulties, the anabolic effect can have a positive effect on the general condition of patients with diabetes. It stimulates rejuvenation and regeneration of internal organs, improves tissue metabolism, which can be a serious help in the fight against the disease.
And for people who have problems with arterial hypertension, we note that somatotropin can increase blood glucose levels, which should be taken into account with caution in arterial hypertension (high blood pressure), since the hormonal drug can increase it.
Recommendations:
- It is necessary to regularly monitor blood pressure during the course.
- Reducing salt intake (sodium chloride) can help lower blood pressure.
Mechanisms of Action of GH: From the Cellular Level to the Anabolic Effect
Somatotropin (STH) has a complex effect on the body, affecting both metabolic processes and tissue growth. It is important to understand that the effects of STH are realized through various mechanisms, both direct and mediated through other hormones.
Direct effect:
STH has a direct effect on cells, increasing lipolysis in lipocytes (fat breakdown) and gluconeogenesis in hepatocytes (glucose formation).
Indirect effect:
The anabolic effect of STH and its effect on growth are mediated by the secretion of insulin-like growth factors (IGF-I and IGF-II).
- IGF-I - secretion of IGF-I is more dependent on STH and plays a more important role in the postnatal period (after birth) than IGF-II. Therefore, the action of STH is mainly mediated by IGF-I.
- Liver is the main source of IGF-I - the main source of IGF-I in the blood is the liver.
- Paracrine and autocrine action of IGF-I - IGF-I, which is formed in many other tissues, can have a paracrine (effect on neighboring cells) and autocrine (effect on the cell itself) effect on cell proliferation (division).
- Transport of IGF-I - IGF-I binds to plasma proteins, which not only participate in its transport, but can also mediate its effect on cells.
The role of IGF-I in the action of STH:
The important role of IGF-I in the action of STH is confirmed by the fact that people with a dysfunction of the IGF-I gene have severe developmental delay (both intrauterine and postnatal), which is not amenable to treatment with STH, but is successfully corrected by recombinant human IGF-I.
How growth hormone works: In simple terms
When somatotropin (growth hormone) enters the body, it binds to special «receivers» (receptors) on the surface of cells. These receptors are present in almost all tissues of the body.
Binding somatotropin to the receptor starts a chain of events inside the cell. Receptors combine in pairs, activate special proteins (JAK2), which, in turn, «switch on» other proteins that transmit the signal further.
This signal reaches the cell nucleus and affects the work of genes responsible for growth, metabolism and other important processes. As a result:
- Cell growth and division accelerates
- Protein synthesis increases
- Fat is broken down
- Blood glucose levels increase
It is important to note that there are different forms of receptors, and their interaction with somatotropin can lead to different results.
In general, the action of a hormonal agent is a complex process that includes binding to receptors, activation of intracellular signaling pathways, and changes in gene function, which ultimately leads to growth and other effects.
Course #1: Somatotropin for Relief and Rejuvenation
Purpose: Achieving a relief figure with sufficient muscle mass, as well as improving muscle elasticity, skin condition and a potential rejuvenation effect.
Preliminary examination:
Before starting the course, it is strongly recommended to undergo an examination and take tests for tumor markers:
- CA 19-9 - a marker that may be elevated in pancreatic, stomach, colon and biliary tract cancer.
- CA 72-4 - used to detect stomach, ovarian and colon cancer.
- Cyfra 21-1 - shows the presence or activity of lung cancer (especially non-small cell) and bladder cancer.
- AFP (Alpha-fetoprotein) - increases in liver, testicular and ovarian cancer.
- CEA (Carcinoembryonic antigen) - may be elevated in colon, lung, breast, pancreatic and ovarian cancer.
Why are they needed before a course of hormonal drugs?
These tests are needed to make sure that there are no hidden oncological processes in the body. Hormonal drugs can accelerate the growth of existing tumors, so it is important to exclude their presence before starting the course. This is a precautionary measure for your safety.
If there are deviations in tumor markers, the use of the product is contraindicated. In this case, it is necessary to undergo an examination by an oncologist.
Course scheme:
1. Beginning:
The course begins with a dosage of 5 IU (international units) daily. Injections are performed subcutaneously. A higher frequency of administration has no advantages.
2. Increasing the dose (if there are no side effects):
In the second or third week, if there are no adverse reactions, the dosage can be increased to 10 IU per day, divided into two injections. Exceeding this dosage is not recommended.
3. Time of administration:
The optimal time for administration is on an empty stomach (approximately 0.5-1 hour before meals, when the glucose level is minimal), in the first half of the day. Often, the first injection is performed immediately after waking up. Also, the period after training is favorable.
4. Duration of the course:
The optimal duration of the course is 3-6 months. A shorter course may not give significant results, and increasing the duration is not recommended due to the possible development of tolerance (production of antibodies that bind somatotropin), the risk of acromegaly and other side effects.
The anabolic agent can suppress the function of the thyroid gland, which negatively affects the results. To prevent this, it is recommended to include Thyroxine in the course at a dose of 25 mcg per day throughout the cycle. This helps to increase the safety and effectiveness of the course and also has a fat-burning effect.
Athletes, our team, would like to note that sugar control is one of the important elements of the course with GH! High doses of the anabolic agent (over 5 IU per day) can increase blood sugar levels and provoke the development of diabetes. In this regard, depending on the dosage and duration of the course, it may be necessary to add insulin to maintain sugar levels within the normal range. However, it should be remembered that uncontrolled insulin intake can lead to hypoglycemic coma.
To control blood sugar levels, it is recommended to use a portable glucometer, measuring sugar levels two or three times a day.
There is also information about Metmorphine on the Internet. In short, the gist is that after consultation with an endocrinologist, it is possible to use Metformin (Glucophage, Glucophage Long) as a softer alternative to insulin. In addition, Metformin helps to accelerate fat burning.
- Sports nutrition and training. To achieve the best results, it is recommended to take a sports nutrition complex for relief, perform 2-3 strength training and 2-3 aerobic training per week.
- Alternative scheme. There is an alternative regimen: long-term use of low doses (2.5-3 IU per day). This approach provides a slower effect but is characterized by a lower risk of side effects and can be considered as a gentle replacement therapy.
Preparation for Injection: Proper Dilution of Somatotropin
Now let’s move on to the most important element of the course - preparation for injection (dilution).
Somatotropin is available as a dry, lyophilized powder and requires dilution before use. Proper dilution is the key to the effectiveness and safety of the drug.
1. Preparation:
Read the information on the ampoule. Make sure you know the amount of powder in the ampoule (in units or milligrams). Remember: 1 mg is approximately equal to 3 IU (1 mg = ~3 units, more precisely 1 mg = 2.7 units). For ease of calculation, you can use formula 1 mg = 3 units.
Then, prepare the tools! You will need:
- An ampoule with lyophilized somatotropin.
- An ampoule with a solvent (bactericidal water, sterile water or vitamin B12).
- Cotton balls soaked in alcohol.
- 3 ml syringe (cubes) with a 1» or 1.5» needle (the thinner the needle, the less painful the injection).
Soak a cotton ball in alcohol and thoroughly wipe the stoppers of the ampoules with somatotropin and solvent.
2. Dilution:
Put the needle on the syringe and draw up the required amount of solvent. The amount of solvent is not critical, but it is important to know exactly how much you have drawn in order to correctly calculate the dosage of the finished solution.
Selecting the amount of solvent:
- Use an amount of solvent that will allow you to easily measure the dosage of the finished solution.
Example:
- 1 ml of solvent per 10 IU of somatotropin: each division (10 units) on a U100 insulin syringe will correspond to 1 IU of somatotropin.
- 2 ml of solvent per 10 IU of somatotropin: each division (20 units) on a U100 insulin syringe will correspond to 1 IU of somatotropin.
- 3 ml of solvent per 10 IU of somatotropin: each division (30 units) on a U100 insulin syringe will correspond to 1 IU of somatotropin.
Injecting the solvent: Inject the solvent into the ampoule with lyophilized somatotropin. Hold the syringe at an angle so that the needle touches the wall of the ampoule and slowly inject the liquid, directing it along the wall, and not directly onto the powder.
Dissolution: After adding all the solvent, gently rotate the ampoule (do not shake too hard!) until the powder is completely dissolved. The finished solution should be clear, without sediment or visible particles.
3. Storage:
- After dilution, store the somatotropin solution in the refrigerator.
- Shelf life of diluted somatotropin:
- Bactericidal water: up to 3 weeks.
- Sterile water: up to 5 days (some manufacturers claim 72 hours).
Important tips:
- Always use sterile instruments and follow hygiene rules.
- Do not shake the ampoule with force, so as not to damage the somatotropin molecules.
- Carefully inspect the solution before use. Do not use it if it has changed color, become cloudy or contains visible particles.
Following these instructions, you will be able to properly dilute somatotropin and prepare it for injection.
Course #2: Somatotropin + Steroids for relief and mass
Courses that include a combination of hormonal and steroid drugs require special attention and control due to the greater severity and increased risk of side effects.
Goal: Achieving a relief figure and simultaneously gaining muscle mass, as well as improving muscle elasticity, skin condition and a potential rejuvenation effect.
Course basis:
The scheme of course #1 (somatotropin - solo) is used as a basis.
Addition of anabolic steroids:
To enhance the anabolic effect, anabolic steroids are added to the course. The most effective in combination with a hormonal substance are considered to be:
- Testosterone enanthate: 250-500 mg per week.
- Sustanon 250: 250-500 mg per week.
- Boldenone: 400 mg per week.
The duration of anabolic steroid use is usually 8 weeks. For more detailed information, it is recommended to read the materials on steroid courses.
Expected effects:
This combination of drugs allows you to increase muscle mass due to significant muscle growth and simultaneous fat burning. Some athletes consider this course to be one of the most powerful due to the synergistic effect. In addition, such a combination is relatively safe for health, since hormonal and steroid drugs have different mechanisms of action, which allows them to be used in moderate doses without causing serious disturbances in hormonal metabolism.
Post-cycle therapy (PCT):
After finishing taking anabolic steroids, PCT is necessary to restore natural testosterone production. Anabolic steroids suppress the body’s own testosterone production. If this process is not restored, it can lead to the loss of muscle mass, decreased libido, depression and other negative consequences. PCT is aimed at stimulating the production of your own testosterone to avoid these negative effects. Clomid or tamoxifen are usually used as drugs for PCT.
These are the drugs that are available in our store and are available for purchase at any time, with fast delivery to the USA and Europe.
Alternative option for relief priority:
If relief is of primary importance, instead of the steroids listed above, you can use:
- Anavar. 30-50 mg per day daily.
- Winstrol. 30 mg per day daily.
These drugs have a lower ability to stimulate muscle growth, but are more effective in burning fat and forming dense, sculpted muscles.
Additional recommendations:
- Diet. Follow a diet to gain muscle mass.
- Training. Train according to a special program that takes into account the specifics of training with steroids.
Alternative scheme:
An alternative solution is to use a hormonal agent immediately after a course of anabolic steroids (both for mass and for drying). This allows you to maximally preserve muscle mass and further increase relief.
How to Properly Give Somatotropin Injections: Step-by-Step Instructions
Proper technique for giving somatotropin (growth hormone) injections is important to ensure the safety and effectiveness of the drug. Injections are usually given subcutaneously, using an insulin syringe.
1. Preparation:
- Wash your hands. Wash your hands thoroughly with soap and running water.
- Prepare the syringe. Draw up the required dose of the anabolic substance into the insulin syringe. Make sure there are no air bubbles in the syringe.
2. Selecting the injection site:
- Abdomen. The abdomen is the most common site for subcutaneous injections, as it is easy to gather a fold of skin.
- Alternating sites. Do not inject it into the same site. Alternate injection sites to avoid irritation and the formation of seals.
3. Giving the injection:
- Form a fold of skin. With your left hand, gather the skin on your abdomen into a fold (about 5 cm).
- Inserting the needle. Insert the needle at a 45-degree angle to the skin fold. Make sure the needle enters under the skin and not into the muscle.
- Injecting the medication. Inject the medication slowly and smoothly, emptying the syringe completely.
- Removing the needle. Carefully remove the needle, holding the skin fold.
- Do not massage the injection site. Do not massage the injection site after removing the needle.
4. After the injection:
- Dispose of the syringe. Dispose of the used syringe in a safe place, inaccessible to children and pets.
When using insulin syringes, it is not necessary to treat the injection site with alcohol, since the puncture is very small and the risk of infection is minimal. These are the recommendations of doctors.
Use only sterile disposable syringes. Do not reuse the same syringe.
If you have any questions or concerns about giving injections, talk to doctor or professional in sport pharmacology.
Course #3: Somatotropin + Fat Burners for Maximum Relief
Goal: Maximum fat burning and shaping of a relief figure, as well as improved muscle elasticity, skin condition and potential rejuvenation effect.
Course basis - the scheme of course #1 (solo somatotropin) is used as a basis.
Addition of fat burners:
To enhance the fat-burning effect, Thyroxine is added to the course.
Its recommended dose is 100-200 mcg per day, divided into 3 doses: in the morning, at lunch and in the evening before 18:00.
In this amount, thyroxine has a pronounced fat-burning effect. Exceeding the dosage is not recommended due to the high risk of side effects and potential destruction of muscle tissue.
And then titrate the dose. The dose of thyroxine should be titrated (gradually increased): start with 50 mcg per day, then increase the dose by 25 mcg every two days until you reach the recommended dose. If side effects occur, the dose of thyroxine should be reduced.
Duration of use: Thyroxine should be taken for no more than 1 month, then gradually reduce the dose by 25 mcg every two days until complete withdrawal.
Alternative fat burners:
Alternative components of the complex can be Clenbuterol and Ephedrine. However, it should be remembered that these drugs significantly accelerate the fat burning process, but at the same time increase the risk of side effects.
For maximum effectiveness of the course, it is necessary:
- Follow a diet:
- The calorie content of the diet should be moderate (such that you usually do not gain or lose weight).
- Limit the consumption of fast carbohydrates and fats.
- Take at least 250 g of protein per day.
- Drink more fluids.
- Do the following workouts:
- 1-2 strength training sessions per week using a split program.
- 2-4 aerobic workouts lasting at least 1 hour.
Regarding the price of Growth Hormone, on average it varies and for one standard (lasting from 3 months) course, you will pay about 1,000 dollars, and believe me, it is definitely worth it!
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Thanks for reading, dear athletes! Good anabolism to all!